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KMID : 0352719920160030198
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Journal of Ginseng Research
1992 Volume.16 No. 3 p.198 ~ p.209
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Study on the Hypoglycemic Action of Ginseng Saponin on Streptozotocin Induced Diabetic Rats (II)
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주충노
윤수희/이향숙/김용덕/이희봉/구자현
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Abstract
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The decreased activities of liver enzymes relating to carbohydrate metabolism such as glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and acetyl CoA carboxylase of streptozotocin injected rats were significantly modified by
the
intraperitoneal injection of ginseng saponin mixture and/or purified ginsenosides. However, several enzymes such as pyruvate kinase, malic enzyme and glycogen phosphorylase were not modified appreciably by the saponin administration, suggesting
that the
effect of ginseng saponin might be depend upon individual enzymes. Examination of liver enzymes by liver perfusing technique using perfusion buffer containing saponin (10-3 ) showed that the ginseng saponin might stimulate insulin biosynthesis as
well
as the related enzyme activities.
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KEYWORD
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